Dr. José Santos García Alvarado
DATOS GENERALES
Nombre: Dr. José Santos García Alvarado
Correo electrónico: This email address is being protected from spambots. You need JavaScript enabled to view it.
Página personal: http://www.microbiosymas.com/santoseng.html
Educación:
1984 Licenciatura en Químico Bacteriólogo Parasitólogo, U.A.N.L.
1988 y 1989 Estancias de Investigación Predoctorales. Food Science Department, University of Masachussetts, E.U.A.
1990 Doctor en Ciencias con Especialidad en Microbiología Médica, U.A.N.L.
1991-1999, 2006 Profesor Visitante en la Universidad de Massachusetts, E.U.A.
1999 Investigador Visitante. National Animal Disease Center, USDA, Ames, Iowa, E.U.A.
Líneas de Investigación:
Fisiología, epidemiología y mecanismos de control de microorganismos de importancia en alimentos. Inocuidad Alimentaria. Antimicrobianos naturales.
Principales Reconocimientos
Miembro del Sistema Nacional de Investigadores, Área Biotecnología y Agropecuarias, Nivel II.
Miembro del Editorial Board de la Revista Journal of Food Protection, de la Revista Microbiological Discovery y del Internet Journal of Microbiology.
Miembro de la Academia Mexicana de las Ciencias.
Asesor del International Foundation for Science, Estocolmo.
Miembro de la H. Junta de Gobierno de la UANL
Vicepresidente de la Asociación Mexicana para la Protección de los Alimentos.
Miembro del Strategy Committee. Institute of Food Technologists. (2011-2013)
Miembro del Section & Affiliate Organization Development Task Force of the Institute of Food Technologists.
International Leadership Award. International Association of Food Protection. 2013
Presidente de la Asociación Mexicana de Ciencia de los Alimentos
Curso que imparte licenciatura y posgrado
Fisiología de Microorganismos (Licenciatura y Posgrado). Microbiología de Alimentos (Posgrado). Sistemas Integrados de Calidad (Posgrado)
PUBLICACIONES
Libros:
1.- Labbe, R.G. and García, S. (Editors). 2001. Guide to Food-borne Pathogens. John Wiley & Sons. New York. ISBN. 0-471-350346. 404 p.
2.- García, S. y N. Heredia. 1999. Bioquímica y Fisiología de Microorganismos, Manual de Laboratorio. Universidad Autónoma de Nuevo León. Facultad de Ciencias Biológicas.
3.- García S., and N. Heredia. 2005. Fisiología de Microorganismos. Manual de Curso. Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, 84 p. ISBN: 970-694-190-8.
4.- Heredia, N. y S. García. 2007. Diagnóstico Microbiológico Moderno: Manual de Laboratorio. UANL. ISBN :978-970-694-443-06.
5.- Norma Heredia, Irene Wesley and Santos García. 2009. Microbiologically Safe Foods. John Wiley & Sons. New York. ISBN: 9780470053331.
6.- Santos Garcia and Norma Heredia. 2009. Fisología de Microorganismos: Manual de Laboratorio. Ed. Trillas. Mexico.
7.- Labbe, R.G. and García, S. (Editors). 2013. Guide to Food-borne Pathogens. 2nd Edition. John Wiley & Sons. New York. In press.
Artículos y Capítulos en Libros:
1.- Heredia, N.L., R.G. Labbe, M.A. Rodríguez y J.S. García-Alvarado. 1991. Growth, sporulation and
enterotoxin production by Clostridium perfringens type A in the presence of bile salts. FEMS Microbiology Letters, 84: 15-22. Link.
2.- García-Alvarado, J.S., R.G. Labbé y M.A. Rodríguez. 1992. Sporulation and enterotoxin production of
Clostridium perfringens type A at 37 and 43°C. Applied and Enviromental Microbiology, 58(4):1411-1414. Link.
3.- García-Alvarado, J.S., M.A. Rodríguez y R.G. Labbé. 1992. Isolation of inclusion bodies from vegetative Clostridium perfringens: partial purification of a 47 kDa inclusion protein. Journal of Applied Bacteriology, 73, 157-162. Link.
4.- Labbé, R.G. y J.S. García-Alvarado. 1992. Influence of temperature on sporulation, enterotoxin formation and spore heat resistance of Clostridium perfringens type A. Proc. 3rd World Congress Foodborne Infections and Intoxications, II:1162-1165.
5.- Heredia, N.L., J.S. García-Alvarado y M.A. Rodríguez. 1992. Técnica inmunoenzimática rápida de tipo "ELISA" para la detección de enterotoxina deClostridium perfringens tipo A. Publicaciones Biológicas, 6(2) :139-141.
6.- García-Alvarado, J.S. Manuel A. Rodríguez, and Ronald G. Labbé. 1992. Influence of Elevated
Temperature on Starch Hydrolysis by Enterotoxin-Positive and Enterotoxin-Negative Strains of Clostridium perfringens Type A. Applied and Environmental Microbiology 58(1) p. 326-330. Link.
7.- Heredia, N.L., J.S. García-Alvarado, y R.G. Labbé. 1994. Improved rapid method for production and
purification of Clostridium perfringens type A enterotoxin. Journal of Microbiological Methods, 20:87-91. Link.
8.- Castro-Franco, R., J.S. García-Alvarado, L.J. Galán-Wong y A. Gallegos-del-Tejo.1995. Efecto sinérgico de extractos de bagazo de Agave lechuguilla Torr. en la actividad insecticida de Bacillus thuringiensis contra Spodoptera frugiperda Smith. PHYTON, International Journal of Experimental Botany, 57 (2):113-119.
9.- Verastegui, M.A., C.A Sánchez-García, N.L. Heredia y J.S. García-Alvarado.1996. Antimicrobial activity of three major plants of the Chihuahuan desert. Journal of Etnopharmacology, 52: 175-177. Link.
10.- Heredia, N.L., G. A. García, R. Luévanos, J.S. García-Alvarado y R. G. Labbé. 1997. Elevation of the heat resistance of vegetative cells and spores of Clostridium perfringens by sublethal heat shock. Journal of Food Protection, 60(8): 998-1000.Link.
11.- Rodríguez-Romo, L.A., N.L. Heredia, R.L. Labbé y J.S. García-Alvarado. 1997. Detection of
enterotoxigenic Clostridium perfringens in spices used in México by dot blotting using a DNA probe. Journal of Food Protection, 61(2):201-204. Link.
12.- Castro-Franco, R., J. S. García Alvarado and L. J. Galan-Wong.1998. An alternative bioinsecticide
formulation to encapsulate Bacillus thuringiensis d-toxin and extracts of Agave lecheguilla Torr. for the
control of Spodoptera frugiperda Smith. PHYTON, International Journal of Experimental Botany, 62(1/2): 71-77.
13.- Heredia, N.L., J.S. García-Alvarado y R. G. Labbé. 1998. Alteration in sporulation, enterotoxin production and protein synthesis by Clostridium perfringenstype A following heat shock. Journal of Food Protection, 61(9):1143-1147. Link.
14.- Maiti, R.K., A. Reyes-García, N.L. Heredia, H. Gómez and J.S. García-Alvarado. 1998. Comparison of the protein profiles of four genotypes of “glossy” sorghum subjected to salinity at seedling stage. International Sorghum and Millets Newsletter, 39: 101-103. Link.
15.- Vela, M., N.L. Heredia, P. Feng, and. J.S. García Alvarado. 1999. DNA probe analysis for the carriage of enterotoxigenic Clostridium perfringens in feces of a Mexican subpopulation. Diagnostic Microbiology and Infectious Disease, 35(2): 101-104. Link.
16.- N.L. Heredia y J.S. García Alvarado. 1999. Clostridium perfringens. In Torres-Vitela, R. (Ed). Agentes Patógenos Transmitidos por Alimentos. Universidad Autónoma de Guadalajara. pp159-169.
17.- S.J. Martínez, J.S. García, N.L. Heredia, L. Villarreal and C. García. 2000. Antifungal activity of extract of Sargassum filipendula. PHYTON, International Journal of Experimental Botany. 66: 179-182.
18.- Villarreal, L., N.L. Heredia and J.S. García-Alvarado. 2000. Changes in protein synthesis and acid
tolerance of Clostridium perfringens type A as a result of an acid shock. International Microbiology 3(2): 113-116. Link.
19.- Castro, R., S. García and L. Galán. 2000. Aportaciones de la Biotecnología de formulados a base de
Bacillus thuringiensis para el control de plagas agrícolas. In: Pedroza, A, J.H. Esparza y Ruiz, J.
Aprovechamiento integral de los recursos naturales en zonas áridas. Universidad Autónoma de Chapingo, Bermejillo, Dgo. México. p. 71-87.
20.- García-Alvarado, J. S. M. J. Verde-Star and N. L. Heredia. 2001. Traditional uses and scientific
knowledge of medicinal plants from Mexico and Central America. A review. Journal of Herbs Spices and
Medicinal Plants, 8 (2/3): 37-89. Link.
21.- Castro, R., C. Meza, M. Lechuga y S. García. 2000. Desarrollo de un medio de cultivo para la
propagación de esporas de hongos enteropatógenos. Revista Chapingo, serie Zonas Áridas. 1(2): 79-84.
22.- García, S., F. Iracheta, F. Galván and N.L. Heredia. 2000. Microbiological survey of retail herbs and
spices from Mexican markets. Journal of Food Protection. 64(1): 99-103. Link.
23.- Limón, J.C., N.L. Heredia, y J.S. García Alvarado. 2001. Cross protection by heat and cold shock to
sublethal temperatures in Clostridium perfringens. Brazilian Journal of Microbiology. 32: 110-112. Link.
24.- Wesche-Ebeling, P., R.K. Maiti, J.S García-Alvarado and N.L. Heredia. 2002. Food and Feed Science. In Maiti, R. and P. Wesche (Ed). Peanut Science. Oxford and IBH Publishing CO. PVT. LTD. New Delhi, India. 243-283.
25.- Fernández-Escartín, E. and J.S. García. 2001. Miscellaneous agents: Brucella, Aeromonas, Plesiomonas, and b-hemolytic streptococci. In García, J.S. and R.G. Labbé (Ed) Guide to Food-borne
Pathogens. John Wiley and Sons. New York. 295-313.
26.- Bathnagar, D. and J.S. García Alvarado.2001. Aspergillus. In García, J.S. and R.G. Labbé (Ed) Guide to Food-borne Pathogens. John Wiley and Sons. New York. pp. 35-50.
27.- Heredia, N.L., S. García, G. Rojas and L. Salazar. 2001. Microbiological condition of ground meat
retailed in Monterrey, Mexico. Journal of Food Protection. 64(8): 1249-1251. Link.
28.- Castro, R., C. Meza, M. Contreras and S. García. 2001. Uso de fitoextractos en el control del crecimiento In Vitro de bacterias enteropatógenas. Revista Chapingo, serie Zonas Áridas. 2(1): 96-99.
29.- Villarreal, L., N.L. Heredia and S. García. 2002. Cold tolerance and changes in rates of synthesis of
individual proteins of Clostridium perfringens as a result of cold pre-treatment. Acta Alimentaria 31: (2)179-184. Link.
30.- Martínez, S., N. Heredia, S. García, S. Moreno, J. Guevara, A. Núñez, L. Cárdenas. 2002. Efecto del
extracto de Ulva fasciata (Chlorophyta) sobre el crecimiento bacteriano y fúngico. PHYTON, International Journal of Experimental Botany. 2001: 163-166. Link
31.- Garcia S., M. Araiza; M. Gomez, N. Heredia. 2002. Inhibition of growth , enterotoxin production, and spore formation of Clostridium perfringens by extracts of medicinal plants. Journal of Food Protection. 65(10):1667-1669. Link.
32.- Valdés-Taméz, V., Foroughbakhch P R., Treviño-Garza, E.J., García-Alvarado, J.S., Alanís-Flores, G.J., Alvarado-Vázquez, M.A. y Jurado-Y, E. 2002. Flora medicinal del municipio de Santiago, Nuevo León, México. Su importancia y distribución en la vegetación. PHYTON, International Journal of Experimental Botany. 2002:173-179.
33.- Heredia, N.L., E. Aréchiga, R.G. Labbé, R.G. and S. García. 2003. Stress proteins of Clostridium
perfringens type A immunoreact with antiserum from rabbits infected with gas gangrene. International
Microbiology. 6:259-261. Link.
34.- Álvarez, G., N.L. Heredia and S. García. 2003. Relationship between the effects of stress induced by
human bile juice and acid treatment in Vibrio cholerae. Journal of Food Protection. 66: 2283-2288. Link.
35.- N. Heredia y S. García. 2004. Métodos Rápidos de Diagnóstico. Manual para el Diagnóstico de
Patógenos en Lácteos y Carnes Mediante PCR. Folleto Técnico No. 5 INIFAP. Págs. 29-33. México. ISBN 1405-1915.
36.- García, S., G. Alarcón, M. Gómez and N. Heredia. 2005. Haematoxylon brasiletto extracts inhibit growth, enterotoxin production, and adhesion of Vibrio cholerae. Food Biotechnology. 19: 15-26. Link.
37.- Sanchez, E., N. Heredia and S. García. 2005. Inhibition of growth and mycotoxin production of
Aspergillus flavus and Aspergillus parasiticus by extracts of Agave species. International Journal of Food
Microbiology. 98:271-279. USA. Link.
38.- Heredia, N., M. Escobar, C. Rodriguez and S. García. 2005. Extracts ofHaematoxylon brasiletto inhibit growth, verotoxin production, and adhesion of enterohemorragic Escherichia coli O157:H7 to HeLa cells. Journal of Food Protection. 68:1346-1351. USA. Link.
39.- García, S. and N. Heredia. 2006. Mycotoxins in Mexico: Epidemiology, management, and control
strategies. Mycopathologia. 162:255-264. Link.
40.- García, S., Alarcón, G., Rodríguez, C. And Heredia, N. 2006. Extracts of Acacia farnesiana and Artemisia ludoviciana inhibit growth, enterotoxin production and adhesion of Vibrio cholerae. World Journal of Microbology & Biotechnology, 22:669-674. Link.
41.- Verastegui, A., S. García, A. Oranday, C. Rivas and N. Heredia. 2008. Species of Agave with
antimicrobial activity against selected pathogenic bacteria and fungi. World Journal of Microbiology &
Biotechnology. 24:1249-1252. Link.
42.- Heredia, N., Ybarra, P., Hernández C. and García, S. 2008. Extracellular protectants produced by
Clostridium perfringens cells at elevated temperatures. Letters in Applied microbiology. 48 (1):133-139. Link.
43.- Garcia S. and N. Heredia. 2009. Overview of foodborne pathogens. In: Heredia, N., I Wesley and S.
Garcia (Eds). Microbiologically Safe Foods. John Wiley and Sons. New York.
44.- Heredia, N. and S. Garcia. 2009. Microbiology of chocolate and sweeteners. In: Heredia, N., I Wesley and S. Garcia (Eds). Microbiologically Safe Foods. John Wiley and Sons. New York.
45.- Sanchez, E., L. Solis, S. Garcia and N. Heredia. 2009. Traditional methods of diagnostic. In: Heredia, N., I Wesley and S. Garcia (Eds). Microbiologically Safe Foods. John Wiley and Sons. New York.
46.- Ramirez, R., Y. Almanza, S. García and N. Heredia. 2009. Adherence and invasion of avian pathogenic Escherichia coli to avian traqueal cells. World J. Microbiology and Biotechnology. 25:1019-1023. Link.
47.- Ramírez, R., Almanza, Y., González R., García, S., and Heredia., N.L. 2009.Avian pathogenic Escherichia coli binds fibronectin and laminin. Veterinary Research communications. 33:379-386. DOI: 10.1007/s11259-008-9180-5. Link.
48.-Malagón, I., García, S. and Heredia N. 2010. Adherence, Invasion, Toxigenic, and Chemotactic
Properties of Mexican Campylobacter Strains. Journal of Food Protection. 73:2093-2098. Link.
49.- Valtierra-Rodríguez, Diana, Heredia N.L., García, S. and Sánchez E. 2010. Reduction of
Campylobacter jejuni and Campylobacter coli in poultry skin by fruit extracts. Journal of Food Protection. 73:477-482. Link.
50.- Sánchez, E., S. García, and N Heredia. 2010. Extracts of edible and medicinal plants damage
membranes of Vibrio cholerae. Applied and Environmental Microbiology. 76:6888-6894. Link.
51.- García, S., and N. Heredia. 2011. Clostridium perfringens: A dynamic foodborne pathogen. Food and Bioprocess Technologies. 4:624-630. DOI: 10.1007/s11947-009-0182-2. Link.
52.- Rosas-Taraco, A., E. Sanchez, N. Heredia, D. Bhatnagar and S. García. 2011. Extracts of Agave
americana demonstrate activities against conidiogenesis and aflatoxin production ofAspergillus
parasiticus. World Mycotoxin Journal.4:37-42. Link.
53.- Limon JC, L. Solís, S. García, and N. Heredia. 2011. Cold tolerance ofClostridium perfringens induced by food additives at neutral pH. Acta Alimentaria, 40:87-94. Link
54.- Solís-Soto, LY, S. García, I. Wesley and N. Heredia. 2011. A charcoal- and blood-free enrichment broth for isolation and PCR detection of Campylobacter jejuni and Campylobacter coli. Journal of Food
Protection. 74-221-227. Link.
55.- Susana Lozano-Muñiz, Norma Heredia and Santos García. 2011. Species ofAgave induced
morphological changes on Aspergillus parasiticus Speare and Aspergillus flavus Link Ex Fries. Journal of
Food Agriculture & Environment. 9:767-770. Link.
56.- Castillo, S.L., N. Heredia, J.F. Contreras and S. García. 2011. Extracts of edible and medicinal plants in inhibition of growth, adherence, and cytotoxin production of Campylobacter jejuni and
Campylobacter coli .Journal of Food Science. 76:421-428 (On line). DOI: 10.1111/j.1750-3841.2011.02229.x Link
57.- Heredia, N.L., y J.S. García Alvarado. 2013. Clostridium perfringens. In Torres-Vitela, R. (Ed). Riesgos Asociados al Consumo de Alimentos. Universidad de Guadalajara. pp. 159-173
58.- Garcia, S., and N. Heredia. Aflatoxins: an overivew. In Dixon JE (Ed) Aflatoxin Control in Animal Feeds with Adsorbent Smectite in Bentonite. American Society of Agronomy. In press.
59.- Gómez-Govea, M. S. Garcia, G. Moreno, O. Tovar, G. Inzunsa and N. Heredia. 2012. Analysis of the microbiological quality of fruits and vegetables expended in Monterrey Mexico. Journal of Food Agriculture & Environment. 10: 152-156. Link.
60.- Perez-Montaño, JA., D. Gonzalez -Aguilar, C. Pacheco-Gallardo, C.A. Campos-Bravo, J. Barba-Leon, S. García, N.L. Heredia and E. Cabrera-Diaz. 2012. Frequency and antimicrobial resistance of Salmonella serotypes on beef carcasses at small abattoirs in Jalisco State, Mexico. Journal of Food Protection. 75: 867-873.Link.
61.- Casillas-Buenrostro, R.M., N. Heredia, S. García, and DA. Benesh. 2012. Efficacy of 3MTM Petrifilm™ AC Plates to detect Geobacillus stearothermophilus in UHT milk. International Dairy Journal. 25:147–149. Link.
62.- Garcia, S., and N. Heredia. 2013. Campylobacter. In: R. Labbe and S. Garcia (Eds). Guide to Foodborne Pathogens. 2nd ed. John Wiley and Sons. New York. In press
63.- Bhatnahar, D., and S. Garcia, S. 2013. Aspergillus and Aflatoxins. In: R. Labbe and S. Garcia (Eds).
Guide to Foodborne Pathogens. 2nd ed. John Wiley and Sons. New York. In press
64.- Orue, N., S. García, P. Feng and N. Heredia. 2013. Decontamination ofSalmonella, Shigella, and Escherichia coli O157:H7 from Leafy Green Vegetables Using Edible Plant Extracts. Journal of Food Science. 78: M290–M296. Link.
65.- García-Heredia, A., N. Orue,, S. García, and N. Heredia. Efficacy of commercial citrus-based
disinfectants to inhibit growth, swarming, and biofilm formation of Salmonella and decontaminate parsley.
Journal of Food Agriculture & Environment. 11(2). In press.
66.- Garcia S. and N. Heredia. Microbiological Safety of vegetables in the field, during harvest and
packaging: a global issue. In: Food Security and Wellness (eds). Gustavo Barbosa-Cánovas, Glaucia
Pastore, Delia Rodrigues-Amaya, Suzana Caetano da Silva Lannes, Rickey Yada, Amauri Rosenthal and
Ken Buckle. Springer. (Submitted by invitation).
67.- Cárdenas, C., K. Molina, N. Heredia and S. García. Evaluation of microbial contamination of tomatoes and peppers at retail markets in Monterrey, Mexico. Journal of Food Protection. In press.
68.- Sánchez, E., M.R. Camacho, N. Heredia and S. García. Antimicrobial activity and mode of action of
extracts of Acacia farnesiana against Vibrio cholerae. Journal of Applied Microbiology. In press.
69.- Castillo, S., N. Heredia, and S. García. 2(5H)-Furanone and epigallocatechin gallate possess anti–quorum-sensing activity against Campylobacter jejuni. Submitted
70.- Castillo, S., N. Heredia, and S. García. Citrus extracts as inhibitors of quorum sensing and virulence
factors of Campylobacter jejuni. Submitted.
71.- Solís, L.Y., N. Heredia, S. García Antimicrobial resistance of Campylobacter jejuni/coli isolated in
Mexico. In preparation.
